We also found that generally male gender, being overweight/obese, central adiposity, TG ≥6.9 mmol/L, non‐HDL‐C ≥3.37 mmol/L, lipid‐lowering medications, pre‐diabetes/T2DM were associated with abnormal ALT using different cutoff points. This evidence concerns the gene GPT and type 2 diabetes mellitus.