Moreover, as hepatocytes (HCs) damage is an integral part of liver fibrosis, we generated HC‐specific Runx2 knockout mice (Runx2△/△HCs) by crossing Runx2ff mice with Alb‐Cre mice to verify whether Runx2 ablation in HCs affects the progress of liver fibrosis. The gene discussed is RUNX2; the disease is Hepatic fibrosis.