Yes‐associated protein‐mediated Runx2 activation is responsible for enhanced cardiac fibroblast proliferation in response to increased ECM stiffness14; on the other hand, Runx2 deficiency is shown to accelerate ureteral obstruction‐induced kidney fibrosis through activating the transforming growth factor‐β (TGF‐β) signalling pathway.15 This evidence concerns the gene RUNX2 and Ureteral obstruction.