We also blocked Itgav expression in HSC specifically by synchronously intravenously injecting vitamin A‐coupled liposomes carrying Itgav‐siRNA (VA‐Lip‐siItgav) and VA‐Lip‐Runx2 in mice for avoiding the broad effect of CWHM‐12, which revealed that siItgav inhibited Runx2‐enhanced hepatic fibrosis significantly as well (Figure S16). Here, ITGAV is linked to Hepatic fibrosis.