ITGAV and Hepatic fibrosis: As the integrin alpha‐V chain, encoded by Itgav, is a major component of five αv integrins, and its expression variation will affect the function of all the five αv integrins,29 we thus further utilised a small molecule inhibitor of αv integrins (CWHM‐12) to identify whether Itgav‐mediated function of αv integrins is indeed downstream of Runx2 in HSC activation and liver fibrosis progress (Figure 7A).