As the integrin alpha‐V chain, encoded by Itgav, is a major component of five αv integrins, and its expression variation will affect the function of all the five αv integrins,29 we thus further utilised a small molecule inhibitor of αv integrins (CWHM‐12) to identify whether Itgav‐mediated function of αv integrins is indeed downstream of Runx2 in HSC activation and liver fibrosis progress (Figure 7A). Here, RUNX2 is linked to Hepatic fibrosis.