To explore the role of Itgav in Runx2‐related HSC activation and liver fibrosis, we first silenced Itgav by using small interference RNA in primary HSC isolated from HBAAV‐ctrl mice and HBAAV‐Runx2 mice, and the data showed that Itgav knockdown significantly blocked the upregulation of α‐SMA induced by Runx2 overexpression (Figure S15). This evidence concerns the gene RUNX2 and Hepatic fibrosis.