SPRY2 and Hepatic fibrosis: As the TGF‐β signalling pathway is one of the most important signals in regulating HSC activation and liver fibrosis process,26 the TGFβ pathway‐related genes transcriptome and ChIP‐seq datasets were integrated, and seven common genes including integrin alpha‐V (Itgav), Thbs1, Lox, Src, Spry2, Smad7 and Npnt were obtained (Figure 6C).