In UVMR, genetically determined insulin resistance (1‐log increment in pmol/L fasting insulin) was associated with increased risks of all six cardiometabolic diseases, with ORs (95% CIs) ranging from 23.98 (10.88–52.86) for diabetes to 2.35 (1.24–4.45) for small vessel stroke, but was not associated with Alzheimer's disease (Table 2, Table S7). This evidence concerns the gene INS and Alzheimer disease.