INS and early-onset autosomal dominant Alzheimer disease: In UVMR, genetically determined insulin resistance (1‐log increment in pmol/L fasting insulin) was associated with increased risks of all six cardiometabolic diseases, with ORs (95% CIs) ranging from 23.98 (10.88–52.86) for diabetes to 2.35 (1.24–4.45) for small vessel stroke, but was not associated with Alzheimer's disease (Table 2, Table S7).