Therefore, our results are in agreement with former studies that showed that Chalcones ameliorate neurodegenerative diseases through critical mechanisms leading to the induction of neurotrophic factors such as BDNF and inhibition of proinflammatory cytokines such as TNFα in the brain (Adelusi et al., 2021; Fontes et al., 2014; Funakoshi‐Tago et al., 2009; Lee et al., 2015). The gene discussed is TNF; the disease is neurodegenerative disease.