It happens when the pancreas stops using insulin effectively, which means the body's cells lose the ability to respond to insulin's efforts to drive glucose into the cells, a condition called insulin resistance leads to a type of metabolic disorder in which the patient has an increased level of sugar (glucose) in blood, which can lead to potential complications that include blindness, heart attacks, strokes, kidney damage, lower limb amputation and nerve damage. Here, INS is linked to metabolic disease.