Similar results were observed in vivo; HO-1 expression in the kidney tissue of DN mice was significantly reduced, compared with that in db/m mice, but it recovered after ADSCs-Exos treatment, indicating that ADSCs-Exos reversed the HG-induced decrease in HO-1 in podocytes and DN renal tissue (Fig. 3B). Here, HMOX1 is linked to liver dysplastic nodule.