A murine model that overexpressed the human α-Syn under the thy1 promoter (Thy1-α-Syn) suggested that the gut microbiome transplants from PD patients into these mice induced parkinsonian-like motor dysfunction and that the microbiome was necessary to induce α-Syn pathology, neuroinflammation and motor defects [33]. Here, THY1 is linked to Parkinson disease.