Although the interaction GWAS results did not show the genetic loci encoding the traditionally well-known GCKR, PNPLA3, and APOE genes in large cohort studies, the locus that formed the same cluster on the Manhattan plot for the four models showed that the loci included the neuregulin 1 (NRG1) and glypican-6 (GPC6) genes, i.e., a genetic locus well-known for its association with the pathogenesis of NAFLD. This evidence concerns the gene APOE and metabolic dysfunction-associated steatotic liver disease.