In this study, we randomly selected 9 participants to explore the differences in PBMC inflammatory phenotypes between obese and non-obesity group, find that CD36 and TLR4 were increased on the surface of lymphocytes and granulocytes in the obesity group, but this was not associated with changes in intracellular NF-κB p65. The gene discussed is TLR4; the disease is obesity due to melanocortin 4 receptor deficiency.