Although this property might not directly result in the trans-phosphorylation of RET, it could result in consecutive activation of RET signaling in the absence of the WT RET-EX, as supported by results of mutagenesis studies and the prevalence of mutations in multiple endocrine neoplasia type 2A (MEN2A) [2, 11, 55]. The gene discussed is RET; the disease is multiple endocrine neoplasia type 2.