Fifty of fusion genes have been reported and 14 involving known cancer genes (ALDH2-ACAD10, BIRC6-SPAST, BIRC6-TTC27, CGNL1-TCF12, CPEB3-IDE, CTNNA1-KDM3B, DNAJB1-PRKACA, LRP5-CHKA, PPFIBP1-STK38L, RNF213-SLC26A11, RXRA-WDR5, SEC16A-NOTCH1, WNK1-ERC1, and ACVR1B-ACVRL1). The gene discussed is RNF213; the disease is cancer.