Among the 111 novel fusion genes, 18 involving known cancer genes (APOH-NKTR, ARHGEF10L-HEG1, C1S-GNAI2, CCND1-FGF19, CHP1-INO80, CPB2-LCP1, KANSL1-AC005324.3, LASP1-NCOR1, LPP-RNF139, PIK3R1-NKD2, QKI-CDC45, RHOA-MST1, RNF139-LPP, RXRA-RAPGEF1, SLC30A7-DPYD, SRSF3-PNPLA1, TCF12-TMOD3, and UBL3-SYNE1) (Table S8). The gene discussed is RAPGEF1; the disease is cancer.