In this study, the expression of PTPRM in different ovarian epithelial tumors and normal ovarian and uterine tube tissues was detected using immunohistochemistry, and the results showed that the highest positive expression rate of PTPRM was found in normal ovarian and uterine tube tissues, followed by benign ovarian epithelial tumors and borderline epithelial ovarian tumors;the lowest positive expression rate was found in EOC, with significant differences(P < 0.05), suggesting that PTPRM may be an important molecular influencing factor in the progression of EOC. The gene discussed is PTPRM; the disease is ovarian epithelial tumor.