Studies in gliomas suggest that PTPRM cleavage promotes malignant glioma development in at least two ways: (1) the disassembly of its extracellular domain, which disrupts intercellular and cell–matrix adhesion, and (2) the reduction of the intrinsic phosphatase activity of the intracellular domain, which antagonises the RTK signaling pathway [20]. The gene discussed is PTPRM; the disease is malignant glioma.