APP and neoplasm: However, for metastatic 4T1 tumors, the tumor suppression rate in the AA@PN + laser group was approximately twice that of the HAuNS@PN + laser group, and the AA@PN + CpG + laser group showed the strongest inhibition of tumor growth, which was attributed to the anti-tumor immune response induced by APP and CpG (Fig. 9c–e).