CD8A and neoplasm: In B16 melanoma and MC38 colorectal adenocarcinoma tumor model mice, hSNPs-treated mice had the slowest tumor growth and the longest survival time compared to the pSNPs-treated group, the cSNPs-treated group, and the group treated with two single drug-loaded nanoparticles administered simultaneously (pSNPs & cSNPs), due to hSNPs treatment significantly increased the proportion of CD8+T cells.