In vitro studies showed that CCL-22 gene expression was downregulated by about 60% in B16-F10 melanoma cells, and CCL-22, IL-10, and TGF-β gene expression was downregulated by about 64%, 50%, and 50% in RAW264.7 macrophages, respectively, after 10 μM CUR@PPC treatment. Here, CCL22 is linked to melanoma.