In summary, the above observations pointed toward an unknown effects of myofiber-intrinsic TGF-β signaling on Vav1-Rac1 efferocytosis signaling in intramuscular macrophages, by directing the production of IL-10 in regenerating myofibers after CTX myoinjury. Here, TGFB1 is linked to cerebrotendinous xanthomatosis.