Furthermore, high MAOA expression (HR 1.73, 95% CI 1.11–2.71; P = 0.016), pT ≥ T2c (HR 2.42, 95% CI 1.41–4.17; P < 0.01), PSA > 20 ng/mL (HR 2.01, 95% CI 1.16–3.47; P = 0.012), GS ≥ 8 (HR 2.60, 95% CI 1.43–4.73; P < 0.01) and pLN positivity (HR 5.73, 95% CI 2.69–12.20; P < 0.01) were independent predictors of poor PFS in high risk PC patients (Table 6). The gene discussed is PLN; the disease is pachyonychia congenita.