HMGB1 and cancer: Astragaloside IV is a cycloartane-type triterpene glycoside with a similar skeleton structure to steroids, usually used as an anti-cancer and anti-diabetic drug due to its potency in inhibiting the expression of interleukin (IL)-1, IL-6 and high mobility group box 1 (HMGB1), as well as the production of nitric oxide (NO) [5].