We further identified negative interactions of increased hs-CRP with high LDL-C on the risk of stroke, low HDL-C, ApoAI, and ApoB on CHD, and higher levels of LDL-C and non-HDL-C on the risk of CVD, suggesting that the combined effects of abnormal lipid levels and increased hs-CRP were smaller than the sum or product of their separate effects [31]. The gene discussed is APOA1; the disease is coronary artery disorder.