In the stratified analysis by age group, increased hs-CRP was significantly associated with an increased hazard of stroke and CVD among subjects aged < 60 years [HR (95% CI): 2.18 (1.37–3.45) and 1.67 (1.16–2.39); all P < 0.05], not among subjects aged ≥ 60 years (P > 0.05) (Supplementary Table 1). The gene discussed is MAP3K14; the disease is Stroke.