Significant multiplicative interactions of HDL-C < 40 mg/dL, ApoAI < 1.60 g/L, and ApoB < 0.70 g/L with increased hs-CRP were also detected for CHD [HRs (95% CIs): 0.499 (0.259–0.963), 0.552 (0.325–0.935), and 0.509 (0.275–0.942), respectively; all P  < 0.05]. The gene discussed is APOB; the disease is coronary artery disorder.