Previous studies have demonstrated that IL-33 plays an essential role in several pregnancy-related diseases, including endometriosis, recurrent pregnancy loss and preeclampsia, etc.(Chen H. et al. 2018; Fock et al. 2013; Granne et al. 2011; Miller J. E. et al. 2017; Salker et al. 2012; Zhao et al. 2021). The gene discussed is IL33; the disease is preeclampsia.