Indeed, fasting during Ramadan was associated with significant reductions in BMI, NAFLD fibrosis scores, FIB4 scores and CRP levels as well as improvements in HOMA-IR in patients with NASH (n=74 fasting, n=81 no fasting) indicating positive effects of TRF in the absence of enforced caloric restriction [117]. Here, CRP is linked to metabolic dysfunction-associated steatohepatitis.