Accordingly, TGF-β1, IL-10 and CCL2 protein levels were significantly increased, and TNFα, IL-6, IL-1β and IL-12p40 protein levels were significantly decreased in tumor tissues in mice with MO-Mettl3 macrophages compared with mice with MO–nc macrophages (Supplementary Fig. 9B). Here, METTL3 is linked to neoplasm.