PDCD1 and infectious otitis media: In addition, these findings were confirmed in another murine AOM/DSS model (Fig. 5I), and the numbers and sizes of macroscopically visible tumors from anti-PD-1 mAb-treated miR-146b−/− mice were significantly decreased compared to those from anti-PD-1 mAb-treated WT mice (Fig. 5J-M).