Considering that NECA-induced collagen production by cultured CFs of PAH rats transcended that obtained in CTRL animals, yet no prevention of the NECA effect was obtained upon blocking A2BAR (with PSB603) and A2AAR (with SCH442416), one may hypothesize the participation of minority A1AR and/or A3AR in this endeavor [15, 59]. Here, ADORA3 is linked to pulmonary arterial hypertension.