In CFs from healthy human subjects, NECA (10 μM) increased the expression of α-SMA and α-1 procollagen, as well as the production of soluble collagen; these effects were effectively blocked by GS-6201 (100 nM), a selective A2BAR antagonist [78, 79], which was also able to attenuate pulmonary fibrosis [70]. Here, ACTA1 is linked to pulmonary fibrosis.