The most significant cytokine-regulated down-regulated DEGs in the KEGG pathway analysis were involved in tuberculosis including BID and MALT1; salmonella infection including ACTR3 and CYTH1; phagosomes including CYBA and ATP6V0B; lipids and atherosclerosis including BID and CYBA; and focal adhesion including MYL12A and FN1. The gene discussed is ACTR3; the disease is atherosclerosis.