FLT3 and acute myeloid leukemia: However, patients with NPM1mut AML and additional FMS-like tyrosine kinase 3 internal tandem duplication especially with a ratio > 0.5 (FLT3-ITDhigh) or adverse structural chromosomal aberrations have a poor outcome with CT and are widely considered as candidates for alloHSCT in first complete remission (1st CR, 1st line patients)5,8.