MAPT and frontotemporal dementia: Although there is considerable evidence that Aβ can induce NLRP3 and caspase-1-associated neuroinflammation49,87,88, recent studies have shown that this inflammatory pathway is also upregulated in patients with primary tauopathy (FTD) and Tau22 transgenic mice, suggesting that NLRP inflammasome and caspase-1 activation is directly related to pathological changes of tau protein56.