KMT2A and leukemia: With respect to the potential contribution of such methods to the development of MoA-based risk assessment models, it may be worth noting that the induction of DNA DSBs has been identified as an intermediate key event in a proposed AOP for the development of infant leukemia, linking interference with topoisomerase II to rearrangements of the mixed-lineage leukemia (MLL) gene (Pelkonen et al. 2017).