Considering that LRRC4, the only identified gene with a single rare deleterious variant in family 1 (Table 1), has been reported to play a critical role in regulating neural function, possibly by interacting with PAR complex, a key modulator of skin neurogenic inflammation26–31, we focused on it to further investigate the role of variant genes in the pathogenesis of rosacea. This evidence concerns the gene LRRC4 and rosacea.