In the present study, based on WGS of 3 large rosacea families (as discovery cohort) and WES of 49 additional small rosacea families (as validation cohort), we identified LRRC4, SH3PXD2A, and SLC26A8, each with a single rare genetic variant, as potential candidate genes for rosacea susceptibility. This evidence concerns the gene LRRC4 and rosacea.