MCOLN1 and lysosomal storage disease: The mucolipin family of the ion channel TRP superfamily (TRPML) includes three members: TRPML1, TRPML2, and TRPML3.62 The molecular weights of TRPMLs are around 65 kDa.63 TRPML1, was cloned during the search for the genetic determinants of the lysosomal storage disease MCOLN.64 Mutations of this protein are characterized by severe neurodegeneration.