Thus, TRPM2-mediated cell death is an important mechanism in the pathogenesis of NAFLD-induced liver injury (Fig. 6).324 However, blockade of TRPM7 inhibits the activation and proliferation of primary hematopoietic stem cells and induces apoptosis in activated cells; ER stress was identified as a possible underlying molecular basis.325 TRPM2 and TRPM7 are valuable future therapeutic targets for NAFLD and serve as basis for discoveries related to in this disease. This evidence concerns the gene TRPM7 and metabolic dysfunction-associated steatotic liver disease.