IL-31 is a key neuroimmune link between TH2 cells and sensory nerves in the generation of T cell-mediated pruritus.543 IL-31-induced pruritus was significantly reduced in Trpv1 and Trpa1 knockout mice.544 This finding suggests that TRPV1 and TRPA1 are involved in immune response. The gene discussed is TRPA1; the disease is Pruritus.