Evidence from functional studies points to the involvement of TRPC3 and TRPC7 in BD.434 Clinical results demonstrated reduced TRPC7 expression in a subgroup of BD patients.435 Interestingly, this reduction was inversely correlated with the basal level of Ca2+ in B lymphocyte lines (BLCLs) from BD patients. The gene discussed is TRPC7; the disease is Behcet disease.