TNF and neuropathic pain: Scholars have proposed the involvement of TRPM8 channels in the DRG, through the regulation of NF-κB signaling, in the pathogenesis of hyperalgesia in neuropathic pain rats.198 Activation of TRPM8, which inhibits nuclear localization of NF-κB, led to the repression of TNF (encoding TNF-α) gene transcription.199