By contrast, TRPV3 does not act as extensively as other channels, and its studies have focused on skin diseases.257 TRPV3 has been suggested as a candidate transducer contributing to pain hypersensitivity associated with inflammatory states.258,259 Analgesic effects were observed in a model of pruritus treated with selective and potent inhibitors of the TRPV3 channel by Han et al.260. The gene discussed is TRPV3; the disease is Pruritus.