The level of 5-HT is higher in the skin of patients with psoriasis than that in healthy individuals.352 Specific inhibition of TRPC4 immediately controlled the neuronal activity induced by α-methyl-5HT in dermal nerve preparations.353 Interestingly, visual signs of skin inflammation, such as erythema and desquamation, were significantly improved after TRPC4 inhibition and were accompanied by a reduction in epidermal thickness and inflammatory cell infiltration. The gene discussed is TRPC4; the disease is dermatitis.