TRPV1 and hypertensive disorder: Volunteers treated with ticlopidine, clopidogrel and prasugrel (TRPA1 agonists) often complained of GI discomfort such as nausea, vomiting, and diarrhea.612 Activation of TRPV1 by RTX has antiemetic and hypothermic effects, but it can also cause hypertension.613 The most frequently reported events in subjects taking NEO6860 (TRPV1 antagonist) orally were feeling of hotness, headache, paresthesia, nausea and dizziness.614 Therefore, current clinical research can focus on the topical delivery of TRP channel modulators, including topical patches, mucosal sprays, and nano-delivery systems.