Plasma adrenaline concentrations and urinary excretion of catecholamine metabolites, which may reduce hypertension, greatly increased in Trpm4 knockout mice.490 Furthermore, in Trpv4 knockout mice, the odds of hypertension induced by inhibition of NOS were greater, which was mainly related to the involvement of TRPV4 in vasodilation,491 this finding suggests the vasoprotective effect of endothelial TRPV4. This evidence concerns the gene NOS2 and hypertensive disorder.