Selective activation of TRPM8 reduces the release of inflammatory neuropeptides, inhibits the release of pro-inflammatory cytokines and chemokines, and prevents the accumulation of leukocytes in the colon.302 Inhibitors of phospholipase A2 (PLA2) reduce the response of TRPM8 to cold and agonists, and lysophospholipids as products of PLA2 have the opposite effect on TRPM8.303 Notably, PLA2 levels are elevated in patients with CD and UC,304 whereas levels of lysophospholipids are clearly decreased.305 These changes may also have implications for the function of TRPM8 during colitis. This evidence concerns the gene TRPM8 and colitis.