TRPA1 and acute kidney injury: In a model of cisplatin-induced nephrotoxicity, blockade of TRPA1 alleviated apoptosis, reduced the levels of IL-1β, IL-6, TNF-α, and interferon (IFN)-γ, decreased the levels of cleaved caspase-3, cleaved poly (ADP-ribose) polymerase PARP, and inducible nitric oxide synthase (iNOS), reduced the expression of p-IKKβ, p-JNK, p-ERK and p-p38, and enhanced the expression of IκBα.195 TRPA1 expression was increased in renal tubular epithelial cells from patients with acute kidney injury.