Since the first cloning of TRPM1 in 1998, tremendous progress has been made in the identification of novel members of the TRPM subfamily and their functions.41 The TRPM subfamily consists of eight members; TRPM1–TRPM8.42 TRPMs have been involved in several physiological and pathological processes, including cellular proliferation,43 temperature sensing,44 vascular development,45 cancer progression,46 neurological diseases,47 endothelial dysfunction,48 inflammation,49 type II diabetes,50 and many other processes. This evidence concerns the gene TRPM1 and endothelial dysfunction.