Increased expression levels of TRPC6 were observed in patients with focal segmental glomerulosclerosis (FSGS),519 membranous nephropathies,520 minimal change nephrosis,521 and diabetic nephropathy.522 TRPC6 mutations are involved in FSGS at the genetic level.523 TRPC 6 plays a cytoprotective role in membranous nephropathy.524 Aberrant expression of TRPC6 channels may be an important causative factor in kidney disease, but its clinical application needs further study. This evidence concerns the gene TRPC6 and focal segmental glomerulosclerosis.