NGF and overactive bladder: TRPV1 plays a role in the pathophysiology and treatment of overactivity of the detrusor muscle.538 TRPV1 expression was significantly elevated in the urothelium of patients with overactive bladder disease.539 NGF-induced bladder overactivity depends on the interaction of NGF with TRPV1.540 In addition, selective antagonism of TRPM8 inhibits the exaggerated activity of mechanosensitive bladder C-fibers and reduces bladder overactivity.541 These studies suggest that TRP channel modulators may be of value in urogenital disorders.