TRPC6 and chronic obstructive pulmonary disease: Notably, TRPC6 mRNA expression significantly increases in alveolar macrophages from COPD patients, whereas there was no difference has been observed in the expressions of other TRPC subfamily members.413,414 TRPC6 is a potential candidate target for COPD, but its role in the regulation of macrophage function under physiological and pathophysiological conditions remains to be determined.