TRPC6 and kidney disorder: TRP channels are related to several aspects of the pathology of diabetes, including insulin release from pancreatic beta cells and secondary diseases such as diabetic neuropathy, nephropathy, and vasculopathy.527 Chung et al.528 observed that the gene expression of TRPC4 was upregulated by 22%, and the protein expressions of TRPC1 and TRPC6 were downregulated by 50% in blood vessels of diabetic patients compared with non-diabetic controls.