Activation of TRPV2 induces the release of nerve growth factor (NGF) and regulated blood-brain barrier (BBB) function, which may be associated with ischemic stroke.457 TRPV4 alleviates ischemic injury by increasing glutamate and overloading Ca2+, thereby reducing neurotoxicity.458 Preservation of microcirculation and BBB function shortly after ischemic stroke is a key neuroprotective effect of TRPV4 inhibition, which suggests a contribution of TRPV4 to postischemic brain injury.459. The gene discussed is NGF; the disease is ischemic stroke.