TRPV1 and Hypertension: Furthermore, impaired TRPV1 signaling may contribute to the pathogenesis of hypertension.487 Anandamide activates TRPV1 on perivascular sensory nerves, which leads to the release of CGRP to reduce vasoconstriction.488 Anandamide also inhibits vasoconstriction by activating the TRPV1 receptor in the endothelium, which causes the acute release of NO.489