TRPC6 and stroke disorder: TRPC channels play an important role in vasospasm in hemorrhagic stroke, neuronal death and survival in ischemic stroke, and thrombin-induced pathological changes in astrocytes, and triggering of stroke by affecting blood pressure and atherosclerosis.444 In Ca2+ imaging experiments, Ca2+ influx through TRPC6 activated MAPK signaling and promoted the neuroprotective chemokine CXCL1,445 which protects nerves following stroke.