Increased NADPH oxidase and superoxide dismutase activities and TRPA1 endogenous agonist levels (hydrogen peroxide and 4-hydroxynonenal) were reported in a mouse model of progressive multiple sclerosis-experimental autoimmune encephalomyelitis.465 Thus, TRPA1 may be involved in depression and anxiety-like behaviors. The gene discussed is TRPA1; the disease is major depressive disorder.