Andreopoulos et al.436 treated BD rats with chronic lithium and TRPC3 protein levels were significantly reduced, whereas mRNA levels were not.437 In a study by Roedding et al. investigated whether TRPC3 expression and function were affected by oxidative stress in BD and control BLCLs; chronic mitochondrial-generated oxidative stress reduced TRPC3 protein levels and Ca2+ influx through these channels, but no significant difference was observed between the two groups.438 Thus, TRPC3 is probably not an ideal target for BD. Here, TRPC3 is linked to Behcet disease.