In contrast to TRPV1 and TRPV4, little is known about TRPV2.410 TRPV2 acts in the early stages of receptor-mediated phagocytosis by macrophages.411 Its relevance to alterations in macrophage responsiveness and host defense in COPD still needs to be determined. This evidence concerns the gene TRPV1 and chronic obstructive pulmonary disease.