Thus, TRPM2-mediated cell death is an important mechanism in the pathogenesis of NAFLD-induced liver injury (Fig. 6).324 However, blockade of TRPM7 inhibits the activation and proliferation of primary hematopoietic stem cells and induces apoptosis in activated cells; ER stress was identified as a possible underlying molecular basis.325 TRPM2 and TRPM7 are valuable future therapeutic targets for NAFLD and serve as basis for discoveries related to in this disease. The gene discussed is TRPM2; the disease is metabolic dysfunction-associated steatotic liver disease.