From previously published studies, FTO plays tumor-promoting roles in various cancers, such as AML [27], glioblastoma [52], breast cancer [53], gastric cancer [54], etc. Li et al. pointed out that the FTO-knockdown decreased undifferentiated NB4 cells (CD11b-/CD14-) by all-trans retinoic acid (ATRA) treatment, otherwise FTO-overexpression increased CD11b-/CD14- cells, indicating that FTO could inhibit ATRA-induced differentiation of APL cells [27]. This evidence concerns the gene ITGAM and acute promyelocytic leukemia.