TSPAN4 and early-onset autosomal dominant Alzheimer disease: However, other amyloid protein, including Aβ1-42 (Aβ42), an analogue of Aβ40 which attributes to Alzheimer’s disease (AD), could not up-regulate migrasome production or TSPAN4 expression in human monocytes, monocyte-derived macrophages (Figs. 2a, b and S4e), or mouse BMDM in either monomer or oligomer (Fig. S8g, h).