Furthermore, the turnover of EGFR from the cell surface into early endosomes was reported after infection of several viruses like Zika virus (Sabino et al, 2021) and influenza virus (Eierhoff et al, 2010), serving as signaling mediator and key control point for viral-induced cellular changes for productive or latent infection. Here, EGFR is linked to disease arising from reactivation of latent virus.