In line with a critical role for EGFR in Spike-RBD signaling that we identified, KD of EGFR also led to a significant reduction of Spike-PP infection, shown by a 52.8% reduction of GFP-positive cells when compared with the scramble controls (NC) 24 h postinfection (Figs 4B and S4G). Here, CHMP5 is linked to infection.