ACE2 and infection: As aforementioned, neurotropism is common in the coronavirus group, and the infection mechanisms include connection, penetration, biosynthesis, maturation, and liberation.2Its main cell-invasion mechanism is mediated by ACE2, which is expressed in some brain regions, such as the motor cortex, substantia nigra, olfactory bulb, solitary tract nucleus, and vagus nerve.7Coronavirus 2 can enter the CNS in two ways: hematogenous dissemination or direct infection of nerve endings (Figure 1,Figure 3).