NLRP3 and cryopyrin-associated periodic syndrome: Also, as previously described (Young et al., 2006a; Tapia-Abellán et al., 2019a), the pathological mutation of NLRP3 D303N associated with cryopyrin-associated periodic syndromes (CAPS) resulted in the spontaneous oligomerization of NLRP3 when expressed in HEK293 cells without any stimulation (Fig. 1 C).