SLC2A1 and Alzheimer disease: In an immunohistochemical study performed using an anti-Glut-1 antibody, high plaque load and decreased blood vessel density were observed, particularly in layer IV of the somatosensory cortex in aged, 18-month-old transgenic AD mice, while younger AD mice did not demonstrate any difference compared to the wild-type mice (Kuznetsova and Schliebs, 2013).