For instance, the PNPLA3 rs738409 C > G and TM6SF2 rs58542926 C > T are two genotypes that increase the risk of developing advanced forms of NAFLD [57], but may also promote the reduction in plasma very-low-density lipoprotein (VLDL) concentrations, thereby reducing the risk of cardiovascular disease in patients with NAFLD [57]. This evidence concerns the gene PNPLA3 and cardiovascular disorder.