Finally, some genetic polymorphisms predisposing individuals to advanced forms of NAFLD, such as patatin-like phospholipase domain-containing protein-3 (PNPLA3) and trans-membrane 6 super family-2 (TM6SF2), may modulate the association between NAFLD and the risk of cardiovascular disease [8, 9•, 57]. Here, TM6SF2 is linked to metabolic dysfunction-associated steatotic liver disease.