Our findings indicate that: [a] corticosteroid treatment does not affect the function of cytotoxic T-cells infiltration and has no significant impact on tumor progression; [b] tumors with downregulated SRC-1 gene had a later tumor recurrence compared to those with upregulated SRC-1 gene, regardless of cytotoxic T-cell infiltration; [c] corticosteroid treatment directly affects SRC-1 gene regulation and indirectly affects cytotoxic T-cells infiltration. The gene discussed is SRC; the disease is neoplasm.