APOE and atherosclerosis: In both, ApoE-/- mice and LDLr-/- mice models of atherosclerosis, liraglutide treatment significantly attenuated atherosclerotic plaque development partly independently of body weight and cholesterol reduction, and transcriptomic analysis showed a reduction of proinflammatory pathways in aortic atherosclerotic tissue, suggesting a direct action on plaque independently of metabolic effects [31].