Finally, the lack of phenotype entirely with no variations neither in metabolic nor reproductive parameters in B cell reconstituted muMt- mice as well as in IgG-recipient T cell-deficient RAG1 KO-/- mice further suggest that the effects of B cells deriving from a PCOS-like environment may be dependent on androgen exposure of other leukocytes to fully promote impairment of metabolic parameters. This evidence concerns the gene RAG1 and polycystic ovary syndrome.