Although this remains purely speculative, as to whether this may be via immune activation related to the disease or a result of the disease driving the production of NAbs of IgM, we have previously shown that prenatal androgen exposure has severe effects on the health of offspring across generations, that is, transgenerational transmission (Risal et al., 2019), and alterations of IgM titers in lupus-prone (MRL/lpr) mice does induce a more severe autoimmunity (Boes, 2000). The gene discussed is CD40LG; the disease is systemic lupus erythematosus.