Through logistic multivariate regression analysis, our study made a novel finding by demonstrating that after adjusting for platelet antibodies, number of platelet transfusions, fever, splenomegaly, bleeding, and infection, the preservation time of APs, IL-6, p62, and BECN1 emerged as independent risk factors influencing PTR in ALL patients. The gene discussed is IL6; the disease is acute lymphoblastic leukemia.