Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2), a highly conserved histone methyltransferase that methylates lysine‐27 of histone H3 (H3‐K27), which has been largely characterized to function as a suppressor of gene transcriptional regulation, implicated in cell differentiation, maintenance of adult stem cell populations, and tumor development.[4]. The gene discussed is EZH2; the disease is neoplasm.