HIF‐1α overexpression is implicated in human hepatocellular carcinoma (HCC).[57] To investigate the biological significance of HI‐104 in the progression of HCC by targeting ATP5A or ATP5B, we performed xenograft models in nude mice with ATP5A or ATP5B stable knock‐out MHCC97‐L cell lines (Figure6A). The gene discussed is ATP5F1B; the disease is hepatocellular carcinoma.