Knockout of ATP5B significantly reduced tumor growth in MHCC97‐L xenograft model, which is similar to those previously reported in the literature.[58] Besides, we observed that HI‐104 reduced the tumor volume and weight in wildtype MHCC97‐L xenograft tumor model with a tolerant weight loss, while almost had no effect in ATP5B KO models, which indicated that HI‐104 possibly inhibited tumor growth through ATP5B (Figure 6A–C, Figure S15, Supporting Information). Here, ATP5F1B is linked to neoplasm.