Previous studies have found that inhibition of the rACCGlu‐ventrolateral periaqueductal gray (vlPAG)8 and rACCGlu‐thalamus7 pathways both reduced anxiety‐like behaviors under chronic pain; unexpectedly, we found that the activity of CaMKIIα neurons was reduced under chronic neuropathic pain with anxiety‐like behaviors, which is at odds with prevailing views regarding pain‐related anxiety driven by glutamatergic hyperexcitability within the ACC.48 This evidence concerns the gene CAMK2A and Anxiety.