PRMT5 and lung cancer: To dissect the function of PRMT5 in angiogenesis during lung cancer development, human umbilical vein ECs (HUVECs) were used in our study because HUVECs are a widely used cell model for studying vasculature and angiogenesis, and HUVECs also express many essential signaling molecules and endothelial markers associated with angiogenesis [22, 23].