To our knowledge, this is the first study to demonstrate that administration of i.v. iron to iron-deficient/deplete perioperative patients with anaemia was associated with increases in \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\dot{\text{V}}$$\end{document}V ̇ O2 peak and peak work rate, along with previously observed increases in [Hb] and tHb-mass. The gene discussed is GSTM1; the disease is anemia.