To investigate whether the observed changes in Oxt neurons were due to augmented neuron-microglia contacts, as previously reported between reactive microglia and proopiomelanocortin (POMC) neurons in mice with diet-induced obesity [58], we evaluated microglial presence surrounding Oxt-ir and AVP-ir neurons. The gene discussed is OXT; the disease is obesity due to melanocortin 4 receptor deficiency.