In this study, we investigated the neuron-glia-vasculature in the PVN of control and T2DM individuals, including neurons expressing oxytocin (Oxt), arginine-vasopressin (AVP), or corticotrophin releasing hormone (CRH), microglia, two subpopulations of astrocytes, and lastly, arteries and arterioles. Here, OXT is linked to type 2 diabetes mellitus.