Indeed, several of the endothelial biomarkers including sTM, Angpt-2, Tie-2, and Angpt-2/Tie-2 ratio were among the top predictor variables predictive of SA-AKI on day 7 in studies by our group that sought to develop models that have integrated PERSEVERE-endothelial biomarkers to develop a unified model to predict risk of multiple organ dysfunctions [20]. Here, TEK is linked to acute kidney injury.