They compared two groups of patients with CS of different aetiologies (Cushing’s disease, adrenal adenoma and carcinoma or ectopic secretion of ACTH) undergoing surgery to treat the hypercortisolism: the first group, with 75 patients, did not received any type of hypocoagulation, and the second group, with 232 patient, received hypocoagulation with non-fractioned heparin during 22 days followed by 4 months of warfarin therapy (or until the remission of the disease). Here, POMC is linked to carcinoma.