PLS1 and early-onset autosomal dominant Alzheimer disease: “Dopaminergic synapse,” “Alzheimer’s disease,” and “pathways of neurodegeneration-multiple diseases” terms were enriched using merged PLS1 − genes, and “pathways in cancer” and “cell adhesion metabolism” terms were enriched with the highest significance using merged PLS1 + genes (Additional file 3: Fig. S21).