Our results for the first time identified cellular heterogeneity in Moyamoya disease peripheral blood and identified potential key genes PTP4A1, SPINT2, CSTB, PLA2G16, GPX1, HN1, LGALS3BP, IFI6, NDRG1, GOLGA2, LGALS3. This evidence concerns the gene IFI6 and Moyamoya disease.