Our results for the first time identified cellular heterogeneity in Moyamoya disease peripheral blood and identified potential key genes PTP4A1, SPINT2, CSTB, PLA2G16, GPX1, HN1, LGALS3BP, IFI6, NDRG1, GOLGA2, LGALS3. The gene discussed is CSTB; the disease is Moyamoya disease.