Our results for the first time identified cellular heterogeneity in Moyamoya disease peripheral blood and identified potential key genes PTP4A1, SPINT2, CSTB, PLA2G16, GPX1, HN1, LGALS3BP, IFI6, NDRG1, GOLGA2, LGALS3. Here, NDRG1 is linked to Moyamoya disease.