To complement our analysis, we explored the time-dependent expression of the four glioma driver genes (APC, HIF1A, TERT and TP53) in HCT116 wild type and HCT116 KO cell lines for the core-clock genes BMAL1, PER2 and NR1D1, as well as their differential expression in each of the KOs compared to the WT cells (Supplementary Fig. 7). This evidence concerns the gene NR1D1 and central nervous system cancer.