In the multi-sample LGG dataset, we observe whole-genome doubling (WGD) events exclusively subclonally, as well as frequent subclonal gains and losses of APC, HIF1A, TERT and TP53. This might indicate the role of the four clock-regulated driver genes in the subclonal diversification and intra-tumour heterogeneity of LGG. This evidence concerns the gene HIF1A and neoplasm.