IDH2 and central nervous system cancer: Variation on the 8q24 locus in a long non-coding RNA CCDC26 raises the risk of developing oligodendrogliomas and astrocytomas with mutant IDH1 or IDH2 [15], and the variant on the 11q23 locus in pleckstrin homology like domain family B member 1 (PHLDB1) elevates the chance of developing IDH-mutant gliomas regardless of the glioma histology [16].