HIF1A and central nervous system cancer: To complement our analysis, we explored the time-dependent expression of the four glioma driver genes (APC, HIF1A, TERT and TP53) in HCT116 wild type and HCT116 KO cell lines for the core-clock genes BMAL1, PER2 and NR1D1, as well as their differential expression in each of the KOs compared to the WT cells (Supplementary Fig. 7).