When focusing on clock regulated drivers in glioma, our results further reveal that in LGG, an early small-scale mutation (SSM) in TP53 is followed by either the loss of TERT or the loss of APC. The loss of HIF1A is an early event, while the loss of TP53 and SSM in APC occur late in the LGG progression. The gene discussed is APC; the disease is central nervous system cancer.