Importantly, we have previously shown that several glycans including GP10, GP16, GP18, GP19, GP20, and GP34 are significantly associated with insulin resistance and T2DM [10], and in this study, we report an association between prediabetes and peak postprandial triglyceride concentrations We therefore investigated if the effect of prediabetes on postprandial triglyceride levels could be mediated in-part by the three specific glycans related to prediabetes (GP9, GP11, and GP32) which are also associated with postprandial triglycerides. The gene discussed is S100A10; the disease is type 2 diabetes mellitus.